A new research document presented on the cover of volume 17, issue 7 of Aging (aging-US) It was published on July 25, 2025, entitled “Systemic Factors on the Influence of Young Human Human Serum in Vitro responses of human skin and bone marrow bone marrow in a microphysiological system of co-cultivation”.
The study, led by the first writer Johanna Ritter and the corresponding writer Elke Grönniger from Beiersdorf AG, Hamburg’s research and development, shows that the ingredients in young human blood can help restore youthful properties to the skin, but only when there are also bone marrow cells. This discovery underlines the role of bone marrow in supporting skin health and can allow new approaches aimed at slowing or reversing visible aging points.
Research has investigated how the factors in the serum of blood, which are already known to affect aging in animal studies, act in human cells. Using an advanced system that mimics human circulation, researchers connect a 3D skin model with a model of three -dimensional bone marrow. They found that only the young human serum was not enough to rejuvenate the skin. However, when there were bone marrow cells, these serum agents changed the activity of these cells, which then secrete proteins that rejuvenated the skin tissue.
“Interestingly, we have identified a significant increase in positive KI67 cells in the dynamic model of the skin co-cultivated with the BM model and young serum compared to the model co-cultivated with BM and old serum, indicating an improved tissue regenerative capacity.”
Detailed analysis has shown that the young serum stimulates the bone marrow to produce a group of 55 proteins, with 7 of them demonstrating the ability to reinforce cell renewal, collagen production and other youth -related features. These proteins included factors that improved energy production in cells and reduced signs of cellular aging. Without the interaction between skin cells and bone marrow, these rejuvenation effects did not result.
This find explains why the previous experiments in mice, where young and old animals shared a blood supply, showed rejuvenation to the organs. It suggests that bone marrow cells are critical messengers who convert signals from blood to effects on other tissues, including the skin.
While these results are preclinical and not from human tests, they offer a starting point for new strategies in regenerative medicine and skin care. By identifying specific proteins that can carry rejuvenating signals, the study shows a new way of dealing with age -related changes. Researchers emphasize that further studies will be needed to confirm these effects on humans and test how these proteins can be safely and effectively applied to future treatments.
Overall, this research is an important step in understanding how new blood serum factors affect human tissue and could guide the development of new methods to maintain healthier skin as people grow older.
Source:
Magazine report:
Ritter, J., et al. (2025). Systemic factors in the youthful influence of human serum. Aging. doi.org/10.18632/aging.206288.
