Penn researchers develop herbal drugs to combat gum disease

Researchers at Penn Dental Medicine have developed a herbal medicine to help treat periodontal diseases, commonly known as gingivitis and periodontitis.

Anti -stimulation treatment or “Senotherapy” consists of an enzyme inhibitor called Dasatinib and a natural plant plant called quercetin, the university reported in a statement April 11th.

“Our findings indicate that Senotherapy offers a very promising approach to maintaining periodontal health,” said Dr. Esra Sahingur of Penn Dental Medicine. “Periodontitis is more than a bacterial infection – driven by immunological and metabolic dysfunction, cellular aging and inflammation. By targeting inflammation and senators, we can disrupt the cycle of chronic diseases and unlock new preventive and preventive preventive potential.

Sahingur believes that the drug could lay the foundations for more targeted and effective treatments and delivery options, especially in high -risk patients, such as older adults, people with diabetes and those who immunosuppresses.

The new treatment is based on previous findings

The new treatment is based on the previous findings of the group. To one Previous studyResearchers have shown that chronic inflammation of the gums can promote a condition associated with aging called “aging”, even in newer tissues. The aging cells have permanently stopped dividing in response to stress and release inflammatory molecules that increase tissue damage, slow healing and accelerate diseases.

“These results are consistent with our previous studies and a growing set of research showing the strong role of natural compounds, such as Quercetin, in promoting oral and systematic health.” Dr. Esra Sahingur.

Treatment works by reducing aging indicators as well as inflammation and bone loss in laboratory and animal models. In one study, the group exposed gum cells to periodontitis -related bacteria. The cells responded to a molecular signature that looks like aging, which the combination of Dasatinib-Quercetin (DQ) has greatly faded. Only Quercetin also had a similar effect.

In aging mice, treatment reduced aging indicators and inflammatory mediators in the gum tissues, restoring them to levels observed in younger animals.

It is important that DQ supplements have also helped to prevent the loss of cellular bones – the bone that supports the teeth – inspiration that Senotherapy can help maintain the structural integrity of the periodontal.

“These results agree with our previous studies and a growing body of research that shows the strong role of natural compounds, such as kbercetin, in promoting oral and systematic health,” Sahingur said.

“Our hope is that these initial clinical trials will provide proof of the concept of leverage the therapeutic potential of natural products – either as autonomous factors or in combined shapes – as reception regulatory strategies to enhance clinical results in managing periodontitis,” he added.

Their findings were published in Newspaper of dental research. Sahingur is now hoping to launch an early -stage clinical trial that focuses on Quercetin and possibly lower, intermittent dasatinib doses to evaluate its safety in periodontal use.

The study included undergraduate and dental students in PENN and was partially supported by the US National Institute of Dental and Craniophilic Research.