Penn researchers work together to create a new treatment option for dental infection causing tooth loss

The Penn School of Dentistry, the School of Engineering and Applied Sciences and the Perelman Medical School have working Together to create a new treatment option for top periodontitis, a chronic dental infection that causes tooth loss and affects more than half of the world population.

The Center for Innovation & Precision Dentistry in Penn recently published a study in the Journal of Clinical Investigation demonstration This permaoxytol, a specific formulation of nanoparticles, reduces top periodontitis. Ferumoxytol is also a FDA -approved drug.

Top periodontitis is an infection caused by biofilm – dense, sticky bacteria communities – deeply connected to the root canal. Root channels are the current course of treatment, however, they create restrictions on success rates due to complications.

Sodium hypochlorite is the disinfectant solution used during the radical channels that can cause complications if not contained in the treatment area, according to Beckir KarabukkPresident and Professor of Endodontics at Dental School.

“Effective disinfection of the root tube is essential for the success of treatment,” Karabucak said. Current processes require mechanical methods and hard disinfectants to eliminate biofilm infection, but if not carefully applied, these solutions can damage the surrounding tissues. ”

During the experimental stage, the Center for Innovation and Dental Dentistry was treated 44 patients with a mixture of Ferumoxytol/H2O2 after procedures that achieved a 99.9% reduction in bacteria without adverse effects.

Chens ChenAssistant Professor of Oral and Maxillofacial Surgery at Dental School, talked about how their initial research of their work led to a much larger finding for the future of dental health.

“What began as a simple research on the possibility of toxicity has evolved into something revolutionary: a treatment capable of eliminating persistent biofilm, while at the same time regenerating the tissue for treatment, which is a new concept for tissue regeneration through the activation of stem cells,” he said.

Hyun Koo, a professor of dental schools, talked about his enthusiasm for the future treatment capabilities that Ferumoxytol could offer.

“Iron oxide nanzes can be a transformative new category of therapeutic that provides both antibiofilm and regenerative tissue properties, offering a regenerative approach to antimicrobial therapy,” Koo said. “The options are unlimited: they are biocompatible, cheap for construction and can be incorporated into various compositions. Expanding the use of nanosomy to other aspects of oral health care.”