Scientists at King’s College London have successfully developed a human tooth in a laboratory for the first time. The main evolution could someday lead to patients to take back their lost teeth by offering an alternative to fills or dental implants
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While many animals can return their teeth throughout life, people usually get only one complete set of adults and once damaged or lost, this is usually the end of the road.
But this may be ready to change.
In a major discovery, scientists at King’s College London have successfully developed a human tooth in a laboratory for the first time, according to one Bbc report.
Growth could open completely new options for those who have lost teeth, offering a more natural alternative to fills or dental implants.
Dr. Ana Angelova-Volponi, director of regenerative dentistry in King’s College, London, believes that the discovery could “revolutionize dental care”.
Unlike fills and implants, which are steady and unable to adapt to changes over time, a biomedical tooth made by a person’s cells could be integrated perfectly into the jaw and repaired as a natural tooth.
But how exactly does this process work? And what obstacles should scientists to overcome before daily treatment in clinics? Let’s take a closer look.
The science behind the natural teeth of the laboratory
The team of researchers at King’s College, in collaboration with Imperial College London, has managed to develop a material that allows cells to communicate with each other.
This new material essentially allows one cell to signal another to begin to convert to a tooth formation cell. This is how scientists are now able to imitate the natural environment of tooth development and recreate it outside the body.
“We have developed this material in collaboration with Imperial College to reproduce the environment around the body cells, known as Matrix,” said Xuechen Zhang, a doctorate student at the Dental, Oral and Craniofacial School School.
“This meant that when we introduced the cultivated cells, they were able to send signals to each other to start the process of forming tooth,” he explained. “Previous attempts have failed, as all the signals were sent with one touch. This new material releases signals slowly over time, reproducing what is happening to the body.”
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Goodbye for fillings and implants?
The likelihood of tooth rejuvenation could change the way dentists treat teeth loss and wear.
“This new technology of rejuvenating teeth is very exciting and could be a player for dentists,” said Saoire O’Toole, a clinical lecturer at King’s College prosthetic, speaking to The BBC.
Zhang also pointed out the disadvantages of today’s solutions. The fills, for example, are not as long as people can hope.
“Over time, they will weaken the structure of the teeth. They will have a limited lifetime and can lead to further decay or sensitivity,” he said. “Implants require invasive surgery and a good combination of implants and cellular bones. Both solutions are artificial and do not fully restore the natural function of the teeth, which may lead to long -term complications.”
Laboratory teeth, on the other hand, would be a completely different story.
“Laboratory teeth will naturally be regenerated, incorporating into the jaw as real teeth,” Zhang added. “They would be stronger, longer and free from risks of rejection, offering a more durable and biologically compatible solution than fillings or implants.”
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Challenges in front
One of the primary challenges is to calculate how to place these laboratory teeth in a patient’s mouth. There are some possible approaches.
“We have different ideas to put teeth in the mouth,” the researchers explained. “We could transplant young teeth to the missing tooth place and let them grow in the mouth. Alternatively, we could create the whole tooth in the laboratory before placing it in the patient’s mouth.”
For both approaches, it is important to start the process of developing teeth in the laboratory at a very early stage.
Whatever the selected method, scientists expect that it could take years before laboratory teeth becomes a reality in dental clinics. However, the discovery marks an important step forward in dental care.
In influx of agencies