When Botox first won FDA’s approval for cosmetic use in 2002, it was mainly used by women in their 40s and 50s.
Now, women in their twenties take the “baby botox”, or smaller amounts for finer results, as a preventive way to prevent aging.
But can Botox get too often to lead to immunity to treatment?
Women flock to the social media to understand the next steps if they are afraid that they have become immune, questioning why they have stopped working and looking for answers – especially if they spend hundreds of dollars on a treatment that does not seem to do the trick.
They blame everything, from the Covid vaccines to the transition to a different injectable, such as Daxxify or Xeomin, or start to try complete.
Theories include antibody building against it after repeated use for its metabolism faster than frequent hard workouts.
Sometimes people are not really immune, but neurotoxin simply reaches faster due to amazing factors, including intense stress.
Dailymail.com has talked to experts about how some women become stinging and how they can prevent it.
When Botox first won the approval of FDA for cosmetic use in 2002, it was mainly used by women in their 40s and 50s

Can it get a fixed botox to lead to immunity to treatment? And most importantly, what can prevent this from happening? (Inventory Picture)
Plastic Surgeon based in New York Dr. Michael Bassiri-Tehrani He explained that patients do not become immune and develop antibodies – instead, they become durable.
It is at risk of happening “the more often you are exposed to the product in higher doses,” the doctor from the luxury office East Side explained.
“People who will give or touch the botox between the normal three months of sessions may be at risk.”
“Another thing that people do not fully realize about Botox is that once it enters the neuromuscular connection it is bound to the nerve endings that feed the muscle. And it doesn’t just go out in three months and all is well, “said Dr. Bassiri-Tehrani.
“It is permanently linked to these nerve endings and what is happening is the new nerve endings that go to the muscles,” the surgeon continued.
“The reason why the reason it reaches three months is not because Botox disappears. It is because the new nerve endings are now encouraging these muscle units and when they reappear the muscle units, they do not reset exactly the same muscle units in exactly the same way.
Dr. Bassiri-tehrani suggests waiting every six months for new nerve endings to root fully and heal.
Lisa Chevalier, the founder of Serious medical spaIt has injected Botox for 17 years in many of the same patients. Manhatanos has seen “a small number of patients receiving higher doses that have resisted Botox and over time and other neuromuscular producers.”

Dr. Bassiri-Tehrani suggests wait every six months for new nerve endings to completely drop and heal before Botox again (stock image)
Lisa had come to patients and tells her that she was “immune” in Botox or that “it just doesn’t work well for them when she did it before”. He then finds that many practices have visited and were not sure if they had botox or other similar substance.
“Botox is the domestic name of neurotransmitters such as Kleenex and advertising and discussion professionals often refer to it, because it is exactly what people know when the patient actually consents and is injected with a brother’s product,” Lisa explained.

Lisa Chevalier, the founder of Sovous Medical Spa, has injected Botox for 17 years
“If the product is handled or diluted inappropriately, it may be less effective, leading to the false impression of resistance,” Lisa warned.
It also depends on whether the trainee you visit is a sketch. “Some practices may charge per region and essentially give customers subclinical installments because they are in line with their pricing,” Lisa said.
Lisa said she is looking for practices that instead charge the unit, which tend to be fairer and transparent.
Lisa has seen true Botox immunity only twice in the 17 years of her exercise, which leads to the effort of another product.
Many women can become so obsessed with the results that they want to return very often, which can lead to resistance.
If one starts from Botox Young Propreatively, Lisa suggests the distance between treatments to avoid resistance.
Lisa has informed that people who are worried about resistance can rotate the brands, avoid over -doses, sticking to the lower effective amount and space therapies properly.

Facialist Jade Haifa told the dailymail.com that throughout her career “she had customers who over time developed immunity to Botox”
Many people believe that they have been immune to Botox when their effects just reach faster.
The actual Botox resistance, where the body produces antibodies to neutralize it, is much rarer.
Factors that destroy the longevity of neuromorphic treatments include faster metabolism, strongly processing, smoking, alcohol consumption, training frequency, sun exposure and high stress.
Facialist Jade Haifa oueslatiBased in New York, she told dailymail.com that throughout her career she had “she had clients who, over time, developed immunity to Botox and therefore requested alternative facial treatments to achieve similar results”.
While “these treatments do not immediately replace botox, they can provide comparable benefits such as skin tightening, wrinkle reduction and overall facial rejuvenation.”
JadeWhich can boast of a whole range of models and influencers as customers, proposes microneedling, which stimulates the production of collagen and elastin, micro -business, which works with the exercise and enhancement of facial muscles and orals, which use deep relaxation and deeper relaxation.
Jade also recommends the use of retinoids, which accelerate the skin cycle, vitamin C to protect the skin from oxidative stress and peptides to help enhance skin structure.
“While Botox immunity is rare, it can occur under specific conditions, such as repeated high doses of botox that can cause the development of antibodies, genetic predispositions or certain medical conditions,” the skin expert confirmed.