Bridging research, perspectives and clinics

The 15th International Conference on Skin Aging and Challenges will be organized on 5-6 November 2024, at the Corinthia Palace in Malta, in collaboration with the International Society for Microbiota (ISM). The conference will explore innovative strategies to understand and combat skin aging. Topics will include targeting senescent cells with senolytics, using extracellular vesicles for rejuvenation, and exploring the benefits of germline and mitochondrial transplantation. International speakers will also delve into the symbiotic relationship between the microbiome and skin health, as well as cutting-edge therapies in phage therapy and iron metabolism.

Skin Challenges 2024 Trends

1. Senolytics: Targeting Senescent Cells

• Mechanisms by which senolytics target and eliminate senescent cells.
• Recent advances in senolytic drugs and their application in aging skin.
• Results of clinical trials and possible side effects of senolytic treatments.

Speakers include:

Karin Scharffetter-Kochanek, Universitätsklinikum Ulm, Germany – Reversing Skin Aging: The Power of Senomorphics and Senolytics

Markus Schosserer, Medical University of Vienna, Austria – The Epitranogram and snoRNAs in cellular and skin aging –

2. Extracellular Vesicles: Messengers for Skin Rejuvenation

• The role of extracellular vesicles (EVs) in skin health and regeneration.
• Methods for the isolation and use of exosomes in antiaging therapies.
• Clinical and preclinical studies demonstrating the efficacy of exosome-based therapies.

3. Skin Microbiota / Mitochondria Transplantation: A Novel Approach

• Techniques and Benefits of Microbial Skin Transplantation.
• Advances in mitochondrial transplantation and its impact on skin aging.
• Combined approaches to restore skin microbiota and mitochondrial function.

Speakers include:

Andrés Caicedo, Universidad San Francisco de Quito USFQ, Ecuador – Exploring mitochondrial dynamics and transport: implications for skin aging and new therapeutic approaches

4. Microbiome & Skin: The Symbiotic Relationship

• The interaction between the skin microbiome and skin health.
• Factors affecting the skin microbiome and strategies to maintain its balance.
• Innovations in skin care products and treatments based on the microbiome.

Speakers include:

Julia Oh, The Jackson Laboratory, USA – Risk Reservoirs of Age, Vulnerability and Infection: The Skin Microbiome of Older Adults

5. Mitochondrial Function: Powerhouses of skin cells

• The importance of mitochondrial function in skin cells and its decline with age.
• Nutritional and lifestyle interventions to enhance mitochondrial function.
• Emerging therapies aimed at boosting mitochondrial health to combat skin aging.

6. Olfactory Receptors & Skin: Sensation & Signaling

• The role of olfactory receptors in skin physiology and aging.
• Mechanisms by which olfactory receptors influence the behavior of skin cells.
• Potential therapeutic applications of targeting olfactory receptors for skin health.

Speakers include:

Marvin Edeas, Institut Cochin, INSERM U1016, Université de Paris, France – Olfactory receptors: Foreign or misunderstood key strategic player?

Shinobu Nakanishi, Shiseido Co., Japan – olfactory receptors, skin and keratinization: What do we know?

7. Phage therapy: Targeting pathogenic bacteria

• The role of phage therapy in dermatology, particularly in the treatment of skin infections.
• Comparative studies of phage therapy versus traditional antibiotic therapies.
• Clinical applications and case studies of food therapy in maintaining skin health.

8. Iron Metabolism: Balancing skin health

• The effect of iron metabolism on skin health and aging.
• Strategies for managing iron levels for optimal skin function.
• Research on iron-related skin conditions and their treatments.

Speakers include:

Leopold Eckhart, Medical University of Vienna, Austria – Skin Iron Metabolism: Recycling vs. Release

9. Artificial intelligence, algorithms and skin aging

• The application of artificial intelligence and machine learning algorithms to skin aging research.
• AI-driven diagnostics and personalized treatment plans for skin health.
• Innovations in AI technology to predict and mitigate skin aging processes.

Speakers include:

Jing-Dong J. Han, Peking University, China – Innovative Thermal Imaging Techniques for Detecting Aging Disorders: ThermaFace Method

10. Another innovative research in skin aging

Substances promising active skin rejuvenation effectively support rapid skin wound healing – Andrey Koptyug, Mid Sweden University, Sweden

Biology Underneath the Skin: Employing Nature’s Approach to Skin Rejuvenation – Jill Helms, Stanford University, USA

Keynote Address

Helmut Sies, Heinrich Heine University Düsseldorf, Germany, known for his pioneering contributions to oxidative stress research, will deliver the keynote address. His presentation “Oxidative Stress: Eustress and Distress” will shed light on the complex balance between beneficial and harmful oxidative stress for skin health.

More information on all Skin Aging & Challenges conference speakers, topics, abstract submission, registration and more: www.skin-challenges.com.