Top periodontitis, a chronic and tough dental infection for treatment, affects more than half of the population worldwide and is the main cause of tooth loss. The root canal is the typical treatment, but existing approaches to the treatment of infection have many restrictions that can cause complications, leading to treatment failure.
Now, researchers at Dentistry; Perelman Medical School; School of Engineering and Applied Sciences They have identified a very promising new therapeutic option that could potentially disrupt current treatments. The team of researchers is part of Center for Innovation and Dental Precision; A common research center between dental medicine and Penn engineering that utilizes mechanics and computational approaches to promote innovation of oral and craniofacial health care.
To one paper Published in Newspaper of clinical researchThey show that Ferumoxytol, an approved FDA nanopartica of iron oxide, significantly reduces infection in patients diagnosed with top periodontitis.
“This is the first study showing the clinical efficacy of a nanotherapy in the treatment of a serious chronic biofilm infection,” he says Hyun (Michel) koo by Penn Dental Medicine. “We have previously found that Ferumoxytol effectively inhibits the pathogenic biofilm in the human mouth, so we asked if these same nanoparticles could deal with an even more difficult biofilm: those hiding in the radical channel.”
Biofilm are dense, sticky bacterial communities associated with surfaces and cause meaningless infections. A protective uterus and the antimicrobial resistance of the germs inhabiting them make it difficult to treat biofilm (such as dental plate). However, when they are deeply formed on the tooth root channel, they are an even greater challenge.
The small size and antimicrobial efficacy of their nanoparticles make excellent candidates for the treatment of biofilm, and the researchers were able to prove that the local applications of zeroxytol in combination with hydrogen peroxide (h (h (h2THE2) Dynamically disturbed biofilm in multiple experimental models.
“Ferumoxytol nanoses-because their unique catalytic (enzymatic) activity-offer new and very effective ways to treat biofilm infections,” he says David Cormode by Penn Medicine and Penn Engineering.
“They represent a fascinating new type of therapeutic factor, since they have new therapeutic effects while low -cost and fixed shelf.”
Currently, sodium hypochlorite (Naocl) is the solution of gold standard disinfection used during the radical channels. However, it can cause complications if not contained in the treatment area, explains Beckir Karambukk by Penn Dental Medicine.
“Effective disinfection of the root canal is essential for the success of treatment. However, the targeting of germs maintaining the structure of teeth is provocative. Current procedures require mechanical methods and hard disinfectants to eliminate biofilm infection Carefully, these solutions can damage the surrounding tissues, “says Karabucak.
Researchers treated 44 patients with peasant periodontitis either with peromoxytol/or2THE2saline or Naocl after undergoing standard endodontic surgeries. The bacterial samples were taken before and after treatment. Found that patients receiving ferumoxytol/h2THE2 It achieved 99.9% of bacterial measurements without experiencing any adverse effects, proving that this treatment is a safer and effective alternative to Naocl.
As part of their process, they found an unexpected result: the nanomas had a positive effect on a population of stem cells found on the edge of the growing tooth root, stimulating their growth and activating them to produce a bone property.
“What began as a simple research on the possibility of toxicity has evolved into something revolutionary: a treatment capable of eliminating persistent biofilm while at the same time regenerating tissues for treatment, which is a new concept for tissue regeneration tissue cells, ”he says Chens Chen by Penn Dental Medicine.
This finding paves the way for investigating the use of Ferumoxytol nanizlers in vital pulp therapy, a viable alternative to the early stages of the disease that prevents patients from going through the treatment of radical canals.
“Enhancing the success of vital pulp therapy with affordable, effective biomaterials can reduce dental care costs. Most importantly, it helps patients maintain their natural teeth structure and lifelong chewing function,” says Karabucak.
Nanoses can also be a very promising approach to repair craniofacial bone abnormalities and the treatment of other bone -related diseases such as osteoporosis, periodontitis and osteopenia caused by autoimmune, given their ability to promote growth of bones.
Koo is excited about the possibilities.
“Iron oxide nanommiums can be a transformative new category of therapeutic that provides both antibiofilm and regenerative tissue properties, offering a regenerative approach to antimicrobial therapy,” he says. “The options are unlimited: they are biocompatible, cheap for construction and can be incorporated into various compositions. Expanding the use of nanosomy to other aspects of oral health care.”
Hyun (Michel) koo is a teacher in Orthodontics department and Pediatrics Departments and Community oral health at the School of Dentistry and the co -founder of the Pennsylvania Innovation and Dentistry.
Bekir Karabucak is a professor and president of Section of endodontics In Penn Dental Medicine.
Chen Chen is an assistant professor at Department of Oral and Maxillofacial Surgery/Pharmacology In Penn Dental Medicine.
David Cormode is Professor of Radiology and Biomedics with an appointment at the School of Medicine and School of Engineering and Applied Sciences in Penn.
Other authors are Alaa Babeer, Ranran Huang, Yuan Liu, Min Jun Oh, Nil Kanatha Pandy, Zhi Ren, Aurea Simon-Soro and Zhenting Xiang of the School of Dentistry at the University of Pennsylvania.
The project was partially supported by the National Institute of Dental and Crance Research (NIDCR) (R01DE025848 and NIDCR R21DE033128) and the Department of Endodontics Research Funds, University of Pennsylvania. The ZR was supported by the Postdoctoral Training Nidcr program (R90DE031532).
